原著論文 / Publication

2023.05.25

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2023年 (令和５年)

• Uemura S, Maenohara S, Inoue K, Ogonuki N, Matoba S, Ogura A, Kurumizaka M, Yamagata K, Sharif J, Koseki H, Ueda K, Unoki M, Sasaki H. UHRF1 is essential for proper cytoplasm architecture and function of mouse oocyte and derived embryo. Life Sci. Alliance, 6(8):e202301904 (2023) 著者による紹介文はコチラ。
• Unoki M, Velasco G, Kori S, Arita K, Daigaku Y, Au Yeung WK, Fujimoto A, Ohashi H, Kubota T, Miyake K, Sasaki H. Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome with distinctive genome-wide DNA hypomethylation. Hum. Mol. Genet. 32(9):1439-1456 (2023)   筆者による紹介文はコチラ。
• Sakashita A, Kitano T, Ishizu H, Guo Y, Masuda H, Ariura M, Murano K, Siomi H. Transcription of MERVL retrotransposons is required for preimplantation embryo development. Nat. Genet. 55(3):484-495 (2023) 筆者による紹介文はコチラ。
• Miyashita R , Nishiyama A, Qin W , Chiba Y, Kori S, Kato N, Konishi C, Kumamoto S, Kozuka-Hata H, Oyama M, Kawasoe Y, Tsurimoto T, Takahashi TS, Leonhardt H, Arita K, Nakanishi M. The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5 eLife. 2023. Feb 3;12:e79013. doi: 10.7554/eLife.79013. 筆者による紹介文はコチラ。

2022年 (令和４年)

• Asanuma T,  Inagaki S, Kakutani T, Aburatani H,  Murakami Y. Tandemly repeated genes promote RNAi-mediated heterochromatin formation via an antisilencing factor, Epe1, in fission yeast. Genes and Development Nov-Dec;36(21-24):1145-1159 (2022) 筆者による紹介文はコチラ。
• Ohishi H, Shimada S, Uchino S, Li J, Sato Y, Shintani M, Owada H, Ohkawa Y, Pertsinidis A, Yamamoto T, Kimura H, Ochiai H. STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity. Nature Communications. 13:7672. (2022). 筆者による紹介文はコチラ。
• Hata K., Kobayashi N., Sugimura K., Qin W., Haxholli D., Chiba Y., Yoshimi S., Hayashi G., Onoda H., Ikegami T., Mulholland CB., Nishiyama A., Nakanishi M., Leonhardt H., Konuma T., Arita K. Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger. Nucleic Acids Res. 50(21):12527-12542 (2022)筆者による紹介文はコチラ。
• Kikuchi A., Onoda H., Yamaguchi K., Kori S., Matsuzawa S., Chiba Y., Tanimoto S., Yoshimi S., Sato H., Yamagata A., Shirouzu M., Adachi N., Sharif J., Koseki H., Nishiyama A., Nakanishi M., Defossez PA., Arita K. Structural basis for activation of DNMT1. Nature Communications. 13,  7130 (2022)  筆者による紹介文はコチラ。
• Tsunemine S,  Nakagawa H,  Suzuki Y,  Murakami Y. The chromatin remodeler RSC prevents ectopic CENP-A propagation into pericentromeric heterochromatin at the chromatin boundary. Nucleic Acids Research. 50 (19): 10914–10928 (2022)  筆者による紹介文はコチラ。
• Hayashi, Y., Kawabata, K.C., Tanaka, Y., Uehara, Y., Kiryu, S., Ota, Y., Yoshioka, Y., Mabuchi, Y., Sugiyama, T., Mikami, K., Tamura, M., Fukushima, T., Asada, S., Takeda, R., Kunisaki, Y., Fukuyama, T., Goyama, S., Yokoyama, K., Tojo, A., Katayama, Y., Arai, F., Nagasawa, T., Ochiya, T., Inoue, D., and Kitamura, T. (2022) MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis. Cell Rep 39:110805 (2022) 筆者による紹介文はコチラ。
• Saito Y, Santosa V, Ishiguro K, Kanemaki MT. MCMBP promotes the assembly of the MCM2–7 hetero-hexamer to ensure robust DNA replication in human cells. eLife, 11:e77393 (2022) 著者による紹介文はコチラ。
• Tanno N, Takemoto K, Takada-Horisawa Y, Shimada R., Fujimura S, Tani N., Takeda N., Araki K, Ishiguro K. FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis. iScience 25(4), 104008 (2022) 著者による紹介文はコチラ。
• To TK, Yamasaki C, Oda S, Tominaga S, Kobayashi A, Tarutani Y, Kakutani T. Local and global crosstalk among heterochromatin marks drives DNA methylome patterning in Arabidopsis. Nat Commun, 13(1): 861 (2022) 著者による紹介文はコチラ。
  
• Negishi T, Kitagawa S, Horii N, Tanaka Y, Haruta N, Sugimoto A, Sawa H, Hayashi KI, Harata M, Kanemaki MT. The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans, Genetics, 220(2):iyab218 (2022) 著者による紹介文はコチラ。
  
• Tanaka, Y., Fukushima, T., Mikami, K., Tsuchiya, S., Tamura, M., Adachi, K., Umemoto, T., Watanabe, N., Morishita, S., Imai, M., Nagata, M., Araki, M., Takizawa, H., Fukuyama, T., Lamagna, C., Masuda, E., Ito, R., Goyama, S., Komatsu, N., Takaku, T., and Kitamura, T. Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors. Nat Commun, 13(1):271 (2022) 著者による紹介文はコチラ。

2021年 (令和３年)

• Matsuzaki H, Miyajima Y, Fukamizu A, Tanimoto K. Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms. Commun Biol, 4(1): 1410 (2021) 著者による紹介文はコチラ。
• Fukushima, T., Tanaka, Y*., Adachi, K., Masuyama, N., Tsuchiya, A., Asada, S., Ishiguro, S., Mori, H., Seki, M., Yachie, N., Goyama, S. and Kitamura, T*. CRISPR/Cas9-mediated base-editing enables a chain reaction through sequential repair of sgRNA scaffold mutations. Sci Rep, 11(1):23889 (2021) 著者による紹介文はコチラ。
• Kori S, Shibahashi Y, Ekimoto T, Nishiyama A, Yoshimi S, Yamaguchi K, Nagatoishi S, Ohta M, Tsumoto K, Nakanishi M, Defossez PA, Ikeguchi M, Arita K. Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1. Bioorganic & Medicinal Chemistry. 52:116500 (2021) 著者による紹介文はコチラ。
• Sato K, Kumar A, Hamada K, Okada C, Oguni A, Machiyama A, Sakuraba S, Nishizawa T, Nureki O, Kono H, Ogata K, Sengoku T. Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2. Nat Commun. 12(1):6605 (2021) 著者による紹介文はコチラ。
• Maehara K, Tomimatsu K, Harada A, Tanaka K, Sato S, Fukuoka M, et al. Modeling population size independent tissue epigenomes by ChIL‐seq with single thin sections. Mol Syst Biol. Nov;17(11):e10323 (2021) 筆者による紹介文はコチラ。
  
• Yokobayashi S, Yabuta Y, Nakagawa M, Okita K, Hu B, Murase Y, Nakamura T, Bourque G, Majewski J, Yamamoto T, Saitou M. Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells. Cell Rep. 2021 Nov 2;37(5):109909. 筆者による紹介文はコチラ。
• Funyu, T., Kanemaru, Y., Onoda, H., Arita, K. Preparation of the ubiquitination-triggered active form of SETDB1 in E. coli for biochemical and structural analyses. J Biochem. 170(5):655-662 (2021) 筆者による紹介文はコチラ。
• Yamamoto, K., Goyama, S., Asada, S., Fujino, T., Yonezawa, T., Sato, N., Takeda, R., Tsuchiya, A., Fukuyama, T., Tanaka, Y., Yokoyama, A., Toya, H., Kon, A., Nannya, Y., Onoguchi-Mizutani, R., Nakagawa, S, Hirose, T., Ogawa, S., Akimitsu, N., and Kitamura, T. Epigenetic regulator ASXL1 interacts with NONO and is involved in paraspeckle formation in hematopoietic cells. Cell Rep. 36(8):109576 (2021)
• Yamashita M, Kuehn HS, Okuyama K, Okada S, Inoue Y, Mitsuiki N, Imai N, Takagi M, Kanegane H, Takeuchi M, Shimojo N, Tsumura M, Padhi AK, Zhang KYJ, Boisson B, Casanova JL, Ohara O, Rosenzweig SD, Taniuchi I, Morio T. A Variant in Human AIOLOS Impairs Adaptive Immunity by Interfering with IKAROS. Nat Immunology Jul;22(7):893-903 (2021)
• Tachiwana H, Dacher M, Maehara K, Harada A, Seto Y, Katayama R, Ohkawa Y, Kimura H, Kurumizaka H, Saitoh N. Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay. eLife 10: e66290 (2021) 筆者による紹介文はコチラ。
•  Horisawa-Takada Y, Kodera C, Takemoto K, Sakashita A, Horisawa K, Maeda R, Shimada R, Usuki S, Fujimura S, Tani N, Matsuura K, Akiyama T, Suzuki A, Niwa H, Tachibana M, Ohba T, Katabuchi H, Namekawa S, Araki K, Ishiguro K*. Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis. Nature Communications 12(1):3184 (2021)  (石黒班、丹羽班、秋山班の領域内共同研究) 筆者による紹介文はコチラ。 研究紹介YouTube動画はコチラとコチラ。
• Oura S, Koyano T, Kodera C, Takada Y, Matsuyama M, Ishiguro K, Ikawa M. KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice. PLOS Genetics 17(5): e1009412 (2021)
• Takada Y, Yaman-Deveci R, Shirakawa T, Sharif J, Tomizawa S, Miura F, Ito T, Ono M, Nakajima K, Koseki Y, Shiotani F, Ishiguro K, Ohbo K, Koseki H. Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing. Development 148(10):dev194605. (2021) (古関班と石黒班の領域内共同研究)　筆者による紹介文はコチラ。
• Imai Y, SaitoK, Takemoto K, Velilla F, Kawasaki T, Ishiguro K, Sakai N.Sycp1 is not required for subtelomeric DNA double-strand breaks but is required for homologous alignment in zebrafish spermatocytes. Front. Cell Dev. Biol. 9, 664377(2021)
• Goto M, Sasaki M*, Kobayashi T*. The S-phase cyclin Clb5 promotes rRNA gene (rDNA) stability by maintaining replication initiation efficiency in rDNA. Molecular and Cellular Biology 41 (5): e00324-20 (2021) 筆者による紹介文はコチラ。
• Mei H, Kozuka C, Hayashi R, Kumon M, Koseki H, Inoue A. H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos. Nat Genet 53(4):539-550 (2021)

• Kumamoto S, Nishiyama A, Chiba Y, Miyashita R, Konishi C, Azuma Y, Nakanishi M. HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation. Nucleic Acids Res 49(9), 5003-5016 (2021) 筆者による紹介文はコチラ。
  

• Narita T, Ito S, Higashijima Y, Chu WK, Neumann K, Walter J, Satpathy S, Liebner T, Hamilton WB, Maskey E, Prus G, Shibata M, Iesmantavicius V, Brickman JM, Anastassiadis K, Koseki H, Choudhary C. Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release. Mol Cell 81(10), 2166-2182.e6 (2021)
• Velasco G, Ulveling D, Rondeau S, Marzin P, Unoki M, Cormier-Daire V, Francastel C, Interplay between histone and DNA Methylation seen through comparative methylomes in rare mendelian disorders, Int J Mol Sci 22(7): 3735 (2021)
• Jones M J K., Gelot C, Munk S, Koren A, Kawasoe Y, George K A, Santos R E, Olsen J V, McCarroll S A, Frattini M G, Takahashi T S, Jallepalli P V. Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication. Molecular Cell 81 (3): P426-441.e8 (2021)
• Oizumi Y, Kaji T, Tashiro S, Takeshita Y, Kanoh J, Complete sequences of Schizosaccharomyces pombe subtelomeres reveal multiple patterns of genome variation. Nature Communications 12 (1), 611 (2021)
• Fujino T, Goyama S, Sugiura Y, Inoue D, Asada S, Yamasaki S, Matsumoto A, Yamaguchi K, Isobe Y, Tsuchiya A, Shikata S, Sato N, Morinaga H, Fukuyama T, Tanaka Y, Fukushima T, Takeda R, Yamamoto K, Honda H, Nishimura EK, Furukawa Y, Shibata T, Abdel-Wahab O, Suematsu M, Kitamura T. Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. Nature Communications 12 (1), 1826 (2021)
• Akiyama T*, Sato S, Ko SBH, Sano O, Sato S, Saito M, Nagai H, Ko MSH, Iwata H* (*corresponding author). Synthetic mRNA‐based differentiation method enables early detection of Parkinson’s phenotypes in neurons derived from Gaucher disease‐induced pluripotent stem cells. STEM CELLS Translational Medicine 10(4), 572-581 (2021)  筆者による紹介文はコチラ。
• Furukawa A, Walinda E, Arita K, Sugase K. Structural dynamics of double-stranded DNA with epigenome modification. Nucleic Acids Res 49 (2):1152–1162 (2021). 筆者による紹介文はコチラ。
• Kuribayashi W, Oshima M, Itokawa N, Koide S, Nakajima-Takagi Y, Yamashita M, Yamazaki S, Rahmutulla B, Miura F, Ito T, Kaneda A, Iwama A. Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche. J Exp Med 218 (3): e20192283 (2021) ：筆者による紹介文はコチラ。
• Aoyama K, Shinoda D, Suzuki E, Nakajima-Takagi Y, Oshima M, Koide S, Rizq O, Si S, Tara S, Sashida G, Iwama A. PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome. Leukemia 35(4), 1156-1165 (2021)

2020年 (令和２年)

• Hirakawa K, Matsuzaki H, Tanimoto K, Transient establishment of imprinted DNA methylation of transgenic human IC1 sequence in mouse during the preimplantation period. Hum Mol Genet 29 (22), 3646-3661 (2020)
• To TK, Nishizawa Y, Inagaki S, Tarutani Y, Tominaga S, Toyoda A, Fujiyama A, Berger F, Kakutani T, RNA interference-independent reprogramming of DNA methylation in Arabidopsis. Nature Plants 6, 1455–1467 (2020)：著者による紹介文はコチラ。
• Mulholland CB, Nishiyama A, Ryan J, Nakamura R, Yiğit Y, Glück IM, Trummer C, Qin W, Bartoschek MD, Traube FR, Parsa E, Ugur E, Modic M, Acharya A, Stolz P, Ziegenhain C, Wierer M, Enard W, Carell T, Lamb DC, Takeda H, Nakanishi M, Bultmann S, Leonhardt H. Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nature Communications 11: 5972 (2020)
• Eto H, Kishi Y*, Yakushiji-Kaminatsui N, Sugishita H, Utsunomiya S, Koseki H,  Gotoh Y*. The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon. Nature Communications Nov 11 2020, 11: 5709 (2020)：筆者による紹介文はコチラ。
• Yesbolatova A, Saito Y, Kitamoto N, Makino-Itou H, Ajima R, Nakano R, Nakaoka H, Fukui K, Gamo K, Tominari Y, Takeuchi H, Saga Y, Hayashi K, Kanemaki M. The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice. Nature Communications Nov 11 2020, 11: 5701 (2020)：筆者による紹介文はコチラ。
• Omori S, Wang T-W, Johmura Y, Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueda S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, Sakamoto T, Yamaguchi K, Hatakeyama S, Shimizu E, Katayama K, Yamada Y, Yamazaki S, Iwasaki K, Miyoshi C, Funato H, Yanagisawa M, Ueno H, Imoto S, Furukawa Y, Yoshida N, Matsushima K, Ueda HR, Miyajima A, Nakanishi M. Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16^high Cells In Vivo, Cell Metab, 32, 814-828 (2020)
• Zhong C, Kayamori K, Koide S, Shinoda D, Oshima M, Nakajima-Takagi Y, Nagai Y, Mimura N, Sakaida E, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Yamaguchi K, Furukawa Y, Lennox W, Sheedy J, Weetall M, Iwama A. Efficacy of the novel tubulin polymerization inhibitor PTC-028 for Mmyelodysplastic syndrome. Cancer Science 111(12):4336-4347 (2020)
  
• Liu M, Kuo F, Capistrano KJ, Kang D, Nixon BG, Shi W, Chou C, Do MH, Stamatiades EG, Gao S, Li S, Chen Y, Hsieh JJ, Hakimi AA, Taniuchi I, Chan TA, Li MO. TGF-β suppresses type 2 immunity to cancer. Nature 587, 115–120 (2020)
• Tanosaki S, Tohyama S, Fujita J, Someya S, Hishiki T, Matsuura T, Nakanishi H, Ohto-Nakanishi T, Akiyama T, Morita Y, Kishino Y, Okada M, Tani H, Soma Y, Nakajima K, Kanazawa H, Sugimoto M, Ko MSH, Suematsu M, Fukuda K. Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells. iScience 23(9):101535 (2020)
• Unoki M, Sharif J, Saito Y, Velasco G, Francastel C, Koseki H, Sasaki H. CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats. Sci. Rep., 10, 17865 (2020)：筆者による紹介文はコチラ。
• Fujiwara Y, Horisawa-Takada Y, Inoue E, Tani N, Shibuya H, Fujimura S, Kariyazono R, Sakata T, Ohta K, Araki K, Okada Y, Ishiguro K.  Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase.  PLOS Genet. 16(9) e1009048 (2020): 筆者による紹介文はコチラ。
  
• Hiraike Y, Waki H, Miyake K, Wada T, Oguchi M, Saito K, Tsutsumi S, Aburatani H, Yamauchi T, Kadowaki T. NFIA differentially controls adipogenic and myogenic gene program through distinct pathways to ensure brown and beige adipocyte differentia tion. PLoS Genet. 16(9) e1009044 (2020)
• Andrews LP, Somasundaram A, Moskovitz JM, Szymczak-Workman AL, Liu C, Cillo AR, Lin H, Normolle DP, Moynihan KD, Taniuchi I, Irvine DJ, Kirkwood JM, Lipson EJ, Ferris RL, Bruno TC, Workman CJ, Vignali DAA.Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding. Sci Immunol. 2020 Jul 17;5(49):eabc2728.
• Tanaka S, Ise W, Inoue T, Ito A, Ono C, Shima Y, Sakakibara S, Nakayama M, Fujii K, Miura I, Sharif J, Koseki H, Koni PA, Raman I, Li QZ, Kubo M, Fujiki K, Nakato R, Shirahige K, Araki H, Miura F, Ito T, Kawakami E, Baba Y, Kurosaki T. Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity. Nat Immunol. 21(8):950-961 (2020)
  
• Tanno N, Kuninaka S, Fujimura S, Takemoto K, Okamura K, Takeda N, Araki K, Araki M, Saya H, Ishiguro K. Phosphorylation of the Anaphase Promoting Complex activator FZR1/ CDH1 is required for Meiosis II entry in mouse male germ cell. Scientific Reports 10, 10094 (2020) 筆者による紹介文はコチラ。
  
• Kajino H, Nagatani T, Oi M, Kujirai T, Kurumizaka H, Nishiyama A, Nakanishi M, Yamatsugu K, Kawashima SA, Kanai M. Synthetic hyperacetylation of nucleosomal histones. RSC Chem. Biol. 1, 56-59 (2020)
• Lee-Thacker S, Jeon H, Choi Y, Taniuchi I, TakaradaT, Yoneda Y, Ko C-M, Jo M. Core Binding Factors are essential for ovulation, luteinization, and female fertility in mice. Sci Rep. 10:9921, (2020)
• Kori S*, Jimenji T*, Ekimoto T*, Sato M, Kusano F, Oda T, Unoki M, Ikeguchi M, Arita K. (*These authors equally contributed to this work.) Serine 298 phosphorylation in linker 2 of UHRF1 regulates ligand-binding property of its tandem Tudor domain. J. Mol. Biol. 432 (14), 4061-4075 (2020) (有田班と中西班の領域内共同研究） 筆者による紹介文はコチラ。
• Takeda R, Asada S, Park SJ, Yokoyama A, Becker HJ, Kanai A, Visconte V,  Hershberger C, Hayashi Y, Yonezawa T, Tamura M, Fukushima T, Tanaka Y, Fukuyama Matsumoto A, Yamasaki S, Nakai K, Yamazaki S, Inaba T, Shibata T, Inoue D, Honda H, Goyama S, Maciejewski JP, Kitamura T. HHEX promotes myeloid transformation in cooperation with mutant ASXL1. Blood. 136 (14): 1670–1684 (2020) 著者による紹介文はコチラ。
• Takemoto K, Tani N, Takada Y, Fujimura S, Tanno N, Yamane M, Okamura K, Sugimoto M, Araki K, Ishiguro K.  Meiosis-specific factor C19orf57/4930432K21Rik/BRME1 modulates localization of RAD51 and DMC1 to DSBs in mouse meiotic recombination.  Cell Reports 31, 107686 (2020) 著者による紹介文はコチラ。
• Nakatake Y, Ko BHS, Sharov A, Wakabayashi S, Murakami M, Sakota M, Chikazawa N, Ookura C, Sato S, Ito N, Ishikawa-Hirayama M, Mak SS, Jakt LM, Ueno T, Hiratsuka K, Matsushita M, Goparaju SK, Akiyama T, Ishiguro K. Oda M, Gouda N, Umezawa A, Akutsu H, Nishimura K, Matoba R, Ohara O, Ko MSH : Generation and profiling of 2,135 human ESC lines for the systematic analyses of cell states perturbed by inducing single transcription factors.  Cell Reports 31, 107655 (2020)
• Collombet S, Ranisavljevic N, Nagano T, Varnai C, Shisode T, Leung W, Piolot T, Galupa R, Borensztein M, Servant N, Fraser P, Ancelin K, Heard E. Parental-to-embryo switch of chromosome organization in early embryogenesis. Nature 580: 142-146 (2020)
  

• Miyajima Y, Ealey NK, Motomura Y, Mochizuki M, Takeno N, Yanagita M, Economides AN, Nakayama M, Koseki H, Moro K. Effects of BMP7 Produced by Group 2 Innate Lymphoid Cells on Adipogenesis. Int Immunol. pii: dxaa013 (2020)
• Seo W, Shimizu K, Kojo S, Okeke A, Kowhi-Shigematsu T, Fujii SI, Taniuchi I. (2020) Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity. Nat Commun. 11: 1562 (2020)
• Nishiyama A, Mulholland CB, Bultmann S, Kori S, Endo A, Saeki Y, Qin W, Trummer C, Chiba Y, Yokoyama H, Kumamoto S, Kawakami T, Hojo H, Nagae G, Aburatani H, Tanaka K, Arita K, Leonhardt H, Nakanishi M. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nat Commun. 11(1): 1222 (2020) (中西班、有田班、油谷班の領域内共同研究）プレスリリース：細胞記憶継承をDNA複製と協調するメカニズムの解明-DNAメチル化酵素をDNA複製部位に正確に配置する新たな仕組み-
• Ishiguro K, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, Sugimoto M, Fujimura S, Hosokawa M, Chuma S, Ko SHM, Araki K, Niwa H. MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells.Dev. Cell. 52 (4): 429-445 (2020)（石黒班と丹羽班の領域内共同研究）プレスリリース：不妊の原因にかかわる遺伝子を発見 -卵子や精子の形成に必要な細胞分裂のメカニズムを解明-  著者による紹介文はコチラ。
• Kennedy J, Georges A, Bassenden A, Vidal S, Berghuis A, Taniuchi I, Majewski J, Lathrop M, Behr M, Langlais D, Gros P. ZBTB7B (ThPOK) is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis. Infect Immun. 88(2): e00845-19 (2020)
• Mishima Y, Brueckner L, Takahashi S, Kawakami T, Otani J, Shinohara A, Takeshita K, Garvilles RG, Watanabe M, Sakai N, Takeshima H, Nachtegael C, Nishiyama A, Nakanishi M, Arita K, Nakashima K, Hojo H, Suetake I. Enhanced processivity of Dnmt1 by monoubiquitinated histone H3. Genes Cells. 25 (1): 22-32 (2020)
• Kojo S, Ohno-Oishi M, Wada H, Nike S, Seo W, Muroi S, Taniuchi I. Constitutive CD8 expression drives innate CD8⁺ T cell differentiation via induction of iNKT2 cells. Life Sci Alliance.3:e202000642 (2020)
  
• Tenno M, Wong A, Ikegaya M, Miyauchi E, Seo W, See P, Kato T, Taida T, Ohno H, Yoshida H, Ginhoux F, Taniuchi I. Essential functions of Runx/Cbfβ in conventional dendritic cells for priming Rorgt⁺ Treg and Th17 cells in the gut. Life Sci. Alliance. 3: e201900441 (2020)

2019年 (令和元年)

• Fukushima T, Tanaka Y, Hamey FK, Chang C-H, Oki T, Asada S, Hayashi Y, Fujino T, Yonezawa T, Takeda R, Kawabata KC, Fukuyama T, Umemoto T, Takubo K, Takizawa H, Goyama S, Ishihama Y, Honda H, Gottgens B, Kitamura T. Discrimination of dormant and active hematopoietic stem cells by G₀ markers reveals dormancy regulation by cytoplasmic calcium. Cell Rep. 29: 4144-4158.e7 (2019) 著者による紹介文はコチラ。
  
• Healy E, Mucha M, Glancy E, Fitzpatrick DJ, Conway E, Neikes HK, Monger C, Van Mierlo G, Baltissen MP, Koseki Y, Vermeulen M, Koseki H, Bracken AP. PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation. Mol Cell. 76(3): 437-452.e6 (2019)
• Mohamed R, Ola R, Oshima M, Nakajima-Takagi Y, Koide S, Saraya A, Isshiki Y, Chiba T, Yamazaki S, Ma A, Jin J, Iwama A, and Mimura N. Akt Inhibition synergizes with PRC2 inhibition in the treatment of multiple myeloma. Cancer Sci. 110: 3695-3707 (2019)
• Hashimoto K, Kouno T, Ikawa T, Hayatsu N, Miyajima Y, Yabukami H, Terooatea T, Sasaki T, Suzuki T, Valentine M, Pascarella G, Okazaki Y, Suzuki H, Shin JW, Minoda A, Taniuchi I, Okano H, Arai Y, Hirose N, Carninci P. Single-cell transcriptomics reveals expansion of cytotoxic CD4 T-cells in supercentenarians. Proc. Natl. Acad. Sci. USA. 116: 24242-24251 (2019) プレスリリース：110歳以上の超長寿者が持つ特殊なT細胞－スーパーセンチナリアンの免疫細胞を1細胞レベルで解析－
• Aktar S, Sasaki H, Unoki M. Identification of ZBTB24 protein domains and motifs for heterochromatin localization and transcriptional activation. Genes Cells. 24 (11): 746-755 (2019) 著者による紹介文はコチラ。
  
• Tamura M, Yonezawa T, Liu X, Asada S, Hayashi Y, Fukuyama T, Tanaka Y, Kitamura T, and Goyama S. Opposing effects of acute versus chronic inhibition of p53 on decitabine’s efficacy in myeloid neoplasms. Sci. Rep. 9:8171 (2019) 著者による紹介文はコチラ。
• Hayashi Y, Goyama S, Liu XX, Asada S, Tanaka Y, Fukuyama T, Wunderlich M, O’Brien E, Mizukawa B, Yamazaki S, Matsumoto A, Yamasaki S, Shibata T, Matsuda K, Sashida G, Takizawa H, Kitamura T. Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia. Nat. Commun. 10: 4689 (2019) 著者による論文紹介はコチラ。